PD-0325901

The MEK inhibitor PD-0325901 selectively binds to and inhibits MEK, which results in inhibition of ERK phosphorylation and inhibition of tumor cell proliferation.PD-0325901 is a second generation-analogue of CI-1040 with an IC50 of 1 nmol/l that is more potent and soluble than CI-1040 in vivo, with a single oral dose providing > 50% inhibition at 24 h.The anticancer activity of this drug has also been demonstrated in a variety of human tumor xenografts bearing BRAF mutations.