PD-0325901

Alternate Name/Synonyms: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide

Appearance: Off-white solid

Formulation: N/A

CAS Number: 301210-10-9

Molecular Formula: C₁₆H₁₄F₃IN₂O₄

Molecular Weight: 482.2

Purity: ≥95% by HPLC

Solubility: DMSO (20 mg/ml) of EtOH (20 mg/ml)

Storage Temp.: -20°C

Shipping Conditions: gel pack

Description: A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (ICâ‚…â‚€ = 0.33 nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells.

Handling: Protect from air and moisture