Paxilline
- 貨號 Cat. No.
- P-450
- 規格 Size
- 0.45 mg 5x0.45mg
Description
Paxilline
A Mycotoxin Blocker of KCa1.1 (BK) Channels
| Product#: | P-450 |
| Sizes: |
| 0.45 mg |
| 5 x 0.45 mg |
| M.W.: | 435.6 |
| Purity: | >98% |
| Bioassay: |
Inhibition of KCa1.1 channels by mycotoxins including Paxilline. |
 |
Left: The effect of 100nM Paxilline (a) Penitrem A (b) and Verruculogen (c) on heterologously expressed BK currents. Time course of current amplitude changes upon sequential applications of the three toxins. Right: Example of current responses to 100ms depolarization before (red) and during (black)perfusion of 500nM Paxilline. |
| References: |
1. | Selala, M.I. et al. (1991) J. Nat. Prod. 54, 207. |
2. | Knaus, H. G. et al. (1994) Biochemistry 33, 5819. |
3. | http://www.alomone.com/System/UpLoadFiles/DGallery/Docs/02_47.pdf |
4. | Hu, H. et al. (2001) J. Neurosci.21, 9585. |
5. | Faber, E. S. L. and Sah, P. (2002) J. Neurosci.22, 1618. |
Paxilline is a selective blocker of KCa1.1 (high-conductance Ca2+-activated K+, BK) channels. It belongs to a set of tremorgenic indole alkaloids which are lipid soluble and also include Pentrium A (#P-650) and Verruculogen (#V-500).2 Paxilline enhanced the electrically induced twitch contractions in guinea pig ileum, without influencing the contractions provoked by exogenous acetylcholine.1 Paxilline was shown to inhibit the peptidyle toxin resistant combination a+b4 channels (for more background see 3) expressed in CHO cells. 4 It was shown to be as potent as Iberiotoxin (#RTI-400) in action potential broadening in hippocampus and amygdala. 4,5