Parthenolide
- 貨號 Cat. No.
- P-250
- 規格 Size
- 10x1mg 5mg 5x5mg
Description
Parthenolide
Nuclear Factor-kB (NF-kB) Pathway Inhibitor
| Product#: | P-250 |
| Sizes: |
| 10 x 1 mg |
| 5 mg |
| 5 x 5 mg |
| M.W.: | 248.3 |
| CAS No.: | [20554-84-1] |
| Structure: |
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| Purity: | >99% |
| Bioassay: |
Parthenolide inhibits NFkB pathway in Jurkat and HeLa cell lines. Jurkat (A) and HeLa (B) cells were preincubated with different concentrations of Parthenolide (#P-250) as indicated in the figure for 60 min. Jurkat cells were stimulated with 100nM PMA (#P-800) and 1mM Ionomycin (#I-700) for 15 min and HeLa cells were stimulated with 4000U/ml TNFa for 10 min. Cell lysates were subjected to Western blot analysis using a phospho-p65NFkB.
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| References: |
1. | Johnson, E. S. et al. (1985) Br. Med. J. 291, 569. |
2. | Biggs, M. J. et al. (1982) Lancet 2, 776. |
3. | Hall, I. H. et al. (1979) J. Pharmacol. Sci. 68, 537. |
4. | Douros, J. and Suffness, M. (1978) Cancer Chemother. Pharmacol. 1, 91. |
5. | Lee, K. H. et al. (1977) Science 196, 533. |
6. | Bork, P. M. et al. (1997) FEBS Lett. 402, 85. |
7. | Hehner, S. P. et al. (1999) J. Immunol. 163, 5617. |
8. | Patel, N.M. et al. (2000) Oncogene 19, 4159. |
9. | Wang, W. et al. (1999) Clin. Cancer Res. 5, 119. |
10. | Wen, J. et al. (2002) J. Biol. Chem. 277, 38954. |
Parthenolide is a sesquiterpene lactone found in Mexican-Indian medicinal plants such as Tanacetum parthenium. It has been widely used in indigenous medical practices for the treatment of migraine, inflammation and tumors.1-4 Parthenolide inhibits IkB kinase (IKK) and IKKb (the upstream activators of the Nuclear Factor-kB (NF-kB) pathway), thus inhibiting Interleukin 1- and tumor necrosis factor a (TNF a) without affecting the activation of p38 and c-Jun N-terminal kinase.5,6
In breast adenocarcinoma and pancreatic tumor cell lines which constitutively express active NF-kB, parthenolide inhibits NF-kB DNA binding and increases sensitivity to chemotherapeutic agents. The sensitivity of these tumor cells to parthenolide is due to the low expression level of the multifunctional detoxification enzyme glutathione S-transferase p caused by inhibition of NF-kB activity.7,10