PAPP-A (A3) Antibody

h1 class=titlePAPP-A (A3) Antibody/h1
div id=node-455 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250257/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
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Format/h4
pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
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h4Description/h4
pPregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Downrsquo;s syndrome (trisomy 21). This antibody is specific for native human PAPP-A. Heat and SDS-denatured PAPP-A are also recognized, but not acid treated PAPP-A./p
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h4Product Citations/h4
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h4Recommended Products/h4
pa href=http://abbiotec.com/antibodies/papp-%281_24%29-antibody250220 PAPP-A (1_24) Antibody/abr /
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h4Alternate Names/h4
pPregnancy-associated plasma protein A; Pappalysin-1(precursor); Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q13219Q13219/abr /
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h4Clonality/h4
pNA/p
h4Antigen/h4
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pPurified human PAPP-A/p
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h4Application Notes/h4
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pIn sandwich ELISA the optimal combination is Product Cat. No. 250257 used as capture antibody and biotinylated Product Cat. No. 250220 used as detection antibody. Product Cat. No. 250257 can also be used as detection antibody in sandwich ELISAnbsp; in combination with a polyclonal antibody against PAPP-A. Product Cat. No. 250257 detect both reduced and unreduced PAPP-A in Western Blotting although the signal to unreduced form is weaker than the one with Product Cat. No. 250219 and Product Cat. No. 250220./p
pE: 1:8,000;/p
pWB: 1:1,000;/p
pIHC: 1:500/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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