PAPP-A (1_24) Antibody

h1 class=titlePAPP-A (1_24) Antibody/h1
div id=node-416 class=node ntype-antibodiesMouse Monoclonal
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h4Catalog Number/h4
pstrong250220/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
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Format/h4
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pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
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h4Description/h4
pPregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The hetreotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Downrsquo;s syndrome (trisomy 21). This antibody is specific for native human PAPP-A. Heat and SDS-denatured PAPP-A is also recognized, but not acid treated PAPP-A ./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pPregnancy-associated plasma protein A; Pappalysin-1(precursor); Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q13219Q13219/abr /
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h4Clonality/h4
p1_24/p
h4Antigen/h4
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pPurified human PAPP-A/p
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h4Application Notes/h4
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pIn sandwich ELISA, Product Cat. No. 250257 is used as the capture antibody and biotinylated Product Cat. No. 250220 as detection antibody. Product Cat. No. 250220 only detects unreduced PAPP-A in Western Blotting. Product Cat. No. 250220 gives the strongest signal in IHC compared to Product Cat. No. 250219 and Product Cat. No. 250257./p
pE: 1:8,000;/p
pWB: 1:1,000;/p
pIHC: 1:200/p
pstrongReacts with/strongnbsp; :H/p
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h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
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