PAPP-A (1_1) Antibody

h1 class=titlePAPP-A (1_1) Antibody/h1
div id=node-415 class=node ntype-antibodiesMouse Monoclonal
div class=contentstyle type=text/css
!--
h4 {
margin: 30px 0 0 0;
padding: 0;
border-top: 1px solid #bbb;
background: #f8f8f8;
}
--/style
div class=product-table
table border=0 cellspacing=10 cellpadding=0 width=100%
tbody
tr
td valign=top width=50%
h4Catalog Number/h4
pstrong250219/strong/p
h4Unit/h4
pstrong0.2 mg /strong/p
h4Format/h4
pEach vial contains 0.2 mg IgG in 0.2 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-A/G affinity chromatography./p
pnbsp;/p
h4Data and Images/h4
/td
td valign=top
h4Description/h4
pPregnancy-associated plasma protein-A (PAPP-A, Insulin-like growth factor binding protein-4 protease, PAPP-A-proMBP complex) is a large heterotetrameric glycoprotein of approximately 500 kDa, which was first discovered in serum from pregnant women. The heterotetramer consists of two PAPP-A subunits and two proMBP subunits. Low maternal serum levels of PAPP-A in first trimester biochemical screening is used as a marker of Downrsquo;s syndrome (trisomy 21). This antibody is specific for native human PAPP-A./p
br style=clear: both /
br style=clear: both /
h4Product Citations/h4
pnbsp;/p
h4Recommended Products/h4
pbr /
nbsp;/p
h4Alternate Names/h4
plt;pgt; Pregnancy-associated plasma protein A; Pappalysin-1(precursor); Insulin-like growth factor-dependent IGF-binding protein 4 protease; IGF-dependent IGFBP-4 protease; IGFBP-4ase lt;/pgt;/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.org/uniprot/Q13219Q13219/abr /
nbsp;/p
h4Clonality/h4
p1_1/p
h4Antigen/h4
pnbsp;/p
pPurified human PAPP-A/p
pnbsp;/p
h4Application Notes/h4
pnbsp;/p
pProduct Cat. No. 250219 only detects unreduced PAPP-A in Western Blotting. In a sandwich ELISA with a polyclonal antibody used as a capture reagent, Product Cat. No. 250219 reacts poorly with PAPP-A in third trimester serum.nbsp;/p
pE: 1:20;/p
pWB: 1:1,000;/p
pIHC: 1:200/p
pstrongReacts with/strongnbsp; :H/p
pnbsp;/p
h4Storage/h4
pStore at 4deg;C. Product is guaranteed 6 months from the date of shipment./p
/td
/tr
/tbody
/table
/div
/div
/div