Panobinostat (LBH589)

Alternate Name/Synonyms: LBH589, LBN-589,NVP-LBH589

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 404950-80-7

Molecular Formula: C₂₁H₂₃N₃O₂

Molecular Weight: 349.43

Purity: ≥99% by HPLC

Solubility: DMSO

Storage Temp.: -20°C

Shipping Conditions: RT

Description: Panobinostat (LBH589) is a highly potent inhibitor of both histone deacetylase 1 (HDAC1) activity and tumour cell proliferation in vitro. The ICâ‚…â‚€ values of HDAC isozymes HDAC1-IP Ac-H4, HDAC8, MALunselective, B61HDAC1 and B12HDAC6 are 0.23±0.06, 283±29, 75±4, 47±5 and 89±12 nM, respectively. And to A2780 proliferation, ICâ‚…â‚€ value is 4.6±1.8 nM.

Handling: Protect from air and moisture