PAK1 Antibody
- 貨號 Cat. No.
- 3248-100
- 規格 Size
- 100 µg
Description
Antibody Target :PAK1
Host: Rabbit
Antibody Type: Polyclonal
Isotype: Rabbit IgG
Antibody Form: Affinity Purified Antibody
Immunogen Sequence: Recombinant human PAK1
Accession#: Q13153
Gene ID: 5058
Appearance: Colorless liquid
Concentration: 0.2 mg/ml
Formulation: 100 µg (0.2 mg/ml) Protein A affinity purified rabbit anti-PAK1 polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 50% glycerol, 1% BSA, 0.02% thimerosal.
Purification: Affinity purified
Species Reactivity: hu
Application: WB/IP
Application & Usage: Western blotting (0.5-4 µg/ml) and immunoprecipitation (10-20 µg/ml). However, the optimal conditions should be determined individually.
Storage Temp.: -20 °C
Shipping : gel pack
Shelf Life: 12 months
Handling: The antibody solution should be gently mixed before use.
Brief Background Descriptions: Human p21-GTPase-activated protein kinase 1 (PAK1) is a functional homolog of STE20 of Saccharomyces cerevisiae. PAK1 is a downstream effector of the Rho-family small GTPases Rac and Cdc42. A serine/threonine kinase, PAK1 induces the formation of filopodia and lamellipodia in Swiss 3T3 cells. PAK1 inhibits myosin light chain kinase, and appears to play a role in the regulation of apoptosis by phosphorylating the death agonist Bad. Membrane targeting of PAK1 induces neurite outgrowth. PAK1 may also regulate NFkB activation.