PAC-1

Alternate Name/Synonyms: 2-[[2-Hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide 4-(phenylmethyl)-1-piperazineacetic acid

Appearance: White solid

Formulation: N/A

CAS Number: 315183-21-2

Molecular Formula: C₂₃H₂₈N₄O₂

Molecular Weight: 392.49

Purity: ≥95% by HPLC

Solubility: DMSO

Storage Temp.: +4°C

Shipping Conditions: RT

Description: Procaspse-activating compound 1 (PAC-1) directly activates procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. In cancer cells, PAC-1 had an IC50 value of 3 nM for induction of cell death, whereas in cells from adjacent normal tissue had IC50 values of 3.2-8.5 µM.

Handling: Protect from air and light