P63 Antibody

h1 class=titleP63 Antibody/h1
div id=node-1414 class=node ntype-antibodiesRabbit Polyclonal
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h4Catalog Number/h4
pstrong250524/strong/p
h4Unit/h4
pstrong0.1 mg/strong/p
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Format/h4
pEach vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4 with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography./p
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h4Data and Images/h4
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pspan class=inline lefta href=http://www.abbiotec.com/image/p63-staining-mouse-corteximg class=image image-medium title=P63 staining in mouse cortex: Paraffin-embedded mouse cortex is stained with p63 Antibody (Cat. No. 250524) used at 1:200 dilution. alt=P63 staining in mouse cortex: Paraffin-embedded mouse cortex is stained with p63 Antibody (Cat. No. 250524) used at 1:200 dilution. width=300 height=226 src=http://www.abbiotec.com/files/images/250524_mousecortex.medium.jpg //aspan style=width: 298px class=captionstrongP63 staining in mouse cortex: /strongParaffin-embedded mouse cortex is stained with p63 Antibody (Cat. No. 250524) used at 1:200 dilution./span/span/p
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h4Description/h4
pTumor protein 63 (p63) acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. p63 in conjunction with p73 initiates p53 dependent apoptosis in response to environmental stimuli such as DNA damage and hypoxia. p63 is also involved in Notch signaling and regulation of epithelial morphogenesis. Defects in p63 are the cause of multiple ectodermal dysplasia syndromes, a group of developmental disorders affecting tissues of ectodermal origin./p
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h4Product Citations/h4
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h4Recommended Products/h4
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h4Alternate Names/h4
pTumor protein 63; p63; Transformation-related protein 63; TP63; Tumor protein p73-like; p73L; p51; p40; Keratinocyte transcription factor KET; Chronic ulcerative stomatitis protein; CUSP; P73H; TP73L/p
h4Accession No./h4
pa class=accession-link target=_blank href=http://www.expasy.ch/uniprot/Q9H3D4Q9H3D4/abr /
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h4Clonality/h4
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h4Antigen/h4
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pKLH-conjugated synthetic peptide encompassing a sequence within the center region of human p63./p
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h4Application Notes/h4
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pE: 1:500-1:1,000/p
pWB: 1:200-1:500/p
pIHC: 1:200-1:500/p
pstrongReacts with/strongnbsp; :H | M | R/p
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h4Storage/h4
pStore at -20deg;C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment./p
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