p57/KIP2 Antibody

p57/KIP2 is a potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to a lesser extent, of the mitotic cyclin B-CDC2. p57/KIP2 is a negative regulator of cell proliferation and plays a role in the maintenance of the non-proliferative state throughout life. Defects in CDKN1C are a cause of Beckwith-Wiedemann syndrome (BWS). BWS is a genetically heterogeneous disorder characterized by anterior abdominal wall defects including exomphalos (omphalocele), pre- and postnatal overgrowth, and macroglossia.