p53 Antibody

Antibody Target :p53

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Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Antibody Form: Affinity Purified Antibody

Immunogen Sequence: Synthetic peptide corresponding to residue surrounding amino acid 375 of human p53

Accession#: EAW90140

Gene ID: 7157

Appearance: Colorless liquid

Concentration: 0.5 mg/ml

Formulation:

Purification: Affinity purified

Species Reactivity: hu/ms/rt/dg/rb

Application: WB

Application & Usage: Western blot analysis (0.5-4 µg/ml). It detects p53 in samples of human, mouse and rat origins. Other applications have not been determined.

Storage Temp.: -20 °C

Shipping : gel pack

Shelf Life: 12 months

Handling: The antibody solution should be gently mixed before use.

Brief Background Descriptions: p53, a 53 kDa protein, binds to a DNA consensus sequence, the p53 response element, and regulates normal cell cycle events by activating transcription of genes involved either in progression through the cell cycle, or causing arrest in G1 when the genome is damaged. In most transformed and tumor cells the concentration of p53 is increased 5-1000 fold over the concentration in normal cells, principally due to the increased half-life (4 hrs) compared to that of wild-type (20 min). p53 localizes in the nucleus, but is detectable at the plasma membrane during mitosis and certain mutations also modulate cytoplasmic/nuclear distribution. p53 downregulates Bcl-2 expression and upregulates Bax expression, but may not always be necessary for apoptosis.

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