p-IKK-a/b (S176) pAb

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h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
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h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
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h3 class=list6_t1Specificity/h3
p class=list6_textp-IKK-a/b (S176) antibody detects endogenous levels of p-IKK-a/b protein./p
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h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
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h3Immunohistochemistry (IHC)/h3
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pImmunohistochemistry (IHC) analyzes of p-IKK-a/b (S176) antibody in paraffin-embedded human breast carcinoma tissue./p
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h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
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h3 class=list6_t1Background/h3
p class=list6_textThe transcription factor NFkappa;B is retained in the cytoplasm in an inactive form by the inhibitory protein Ikappa;B. Activation of NFkappa;B requires that Ikappa;B be phosphorylated on specific serine residues, which results in targeted degradation of Ikappa;B. Ikappa;B kinase alpha; (IKKalpha;) interacts with Ikappa;B-alpha; and specifically phosphorylates Ikappa;B-alpha; on the sites that trigger its degradation, Serines 32 and 36. The functional IKK complex contains three subunits, designated IKKalpha;, IKKbeta; and IKKgamma; (also designated NEMO); each appears to make essential contributions to Ikappa;B phosphorylation. NFkappa;B inducing kinase (NIK) phosphorylates IKKalpha; at Serine 176./p
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