p-beta-catenin (T41/S45) pAb
- 貨號 Cat. No.
- BS5057
- 規格 Size
- 100 μg
- 品牌 Brand
- Bioworld
Description
div class=list6_content
div class=list6_li
h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
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h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
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h3 class=list6_t1Specificity/h3
p class=list6_textp-beta-catenin (T41/S45) antibody detects endogenous levels of p-beta-catenin protein./p
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h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
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div id=IHCpic
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h3Immunohistochemistry (IHC)/h3
img id=ipic src=http://www.bioworlde.com/upload/ihc/5057.jpg width=240 height=180 alt= //div
pImmunohistochemistry (IHC) analyz es of p-beta-catenin (T41/S45) antibody in paraffin-embedded human plung adenocarcinoma tissue./p
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h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
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div class=list6_li
h3 class=list6_t1Background/h3
p class=list6_textThe catenins, alpha;, beta; and gamma;, are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play critical roles in mediating cellular adhesion. beta;-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta;-catenin also forms complexes with the tumor suppressor protein APC. Amino acid alterations at residues around Ser 33, one of the targets for phosphorylation of glycogen synthase kinase-3beta;, result in accumulation of the beta;-catenin protein in the cytoplasm and nucleus. Pin1 is a novel regulator of beta;-catenin signaling that directly binds a phosphorylated Ser-Pro motif next to the APC-binding site in beta;-catenin, inhibiting the interaction with APC and increasing beta;-catenin translocation into the nucleus. Thus, Pin1 overexpression may contribute to the upregulation of beta;-catenin in tumors such as breast cancer./p
/div
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div class=list6_li
h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
/div
div class=list6_li
h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
/div
div class=list6_li
h3 class=list6_t1Specificity/h3
p class=list6_textp-beta-catenin (T41/S45) antibody detects endogenous levels of p-beta-catenin protein./p
/div
div class=list6_li
h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
/div
div id=pic
div id=IHCpic
div class=imagecontainer
h3Immunohistochemistry (IHC)/h3
img id=ipic src=http://www.bioworlde.com/upload/ihc/5057.jpg width=240 height=180 alt= //div
pImmunohistochemistry (IHC) analyz es of p-beta-catenin (T41/S45) antibody in paraffin-embedded human plung adenocarcinoma tissue./p
/div
/div
div class=list6_li
h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
/div
div class=list6_li
h3 class=list6_t1Background/h3
p class=list6_textThe catenins, alpha;, beta; and gamma;, are proteins that bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play critical roles in mediating cellular adhesion. beta;-catenin associates with the cytoplasmic portion of E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. beta;-catenin also forms complexes with the tumor suppressor protein APC. Amino acid alterations at residues around Ser 33, one of the targets for phosphorylation of glycogen synthase kinase-3beta;, result in accumulation of the beta;-catenin protein in the cytoplasm and nucleus. Pin1 is a novel regulator of beta;-catenin signaling that directly binds a phosphorylated Ser-Pro motif next to the APC-binding site in beta;-catenin, inhibiting the interaction with APC and increasing beta;-catenin translocation into the nucleus. Thus, Pin1 overexpression may contribute to the upregulation of beta;-catenin in tumors such as breast cancer./p
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