p-Abl1 (Y204) pAb
- 貨號 Cat. No.
- BS5049
- 規格 Size
- 100 μg
- 品牌 Brand
- Bioworld
Description
div class=list6_content
div class=list6_li
h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
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div class=list6_li
h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
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h3 class=list6_t1Specificity/h3
p class=list6_textp-Abl1 (Y204) antibody detects endogenous levels of p-Abl1 protein./p
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h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
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div id=IHCpic
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h3Immunohistochemistry (IHC)/h3
img id=ipic src=http://www.bioworlde.com/upload/ihc/5049.jpg width=240 height=180 alt= //div
pImmunohistochemistry (IHC) analyzes of p-Abl1 (Y204) antibody in paraffin-embedded human breast carcinoma tissue./p
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div class=list6_li
h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
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div class=list6_li
h3 class=list6_t1Background/h3
p class=list6_textThe Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac./p
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/div
div class=list6_li
h3 class=list6_t1Product/h3
p class=list6_text1 mg/ml in Phosphate buffered saline (PBS) with 15 mM sodium azide, approx. pH 7.2./p
/div
div class=list6_li
h3 class=list6_t1Purification amp; Purity/h3
p class=list6_textThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is gt; 95% (by SDS-PAGE)./p
/div
div class=list6_li
h3 class=list6_t1Specificity/h3
p class=list6_textp-Abl1 (Y204) antibody detects endogenous levels of p-Abl1 protein./p
/div
div class=list6_li
h3 class=list6_t1Applications (Recommended Dilutions)/h3
p class=list6_textIHC: 1:50~1:200/p
/div
div id=pic
div id=IHCpic
div class=imagecontainer
h3Immunohistochemistry (IHC)/h3
img id=ipic src=http://www.bioworlde.com/upload/ihc/5049.jpg width=240 height=180 alt= //div
pImmunohistochemistry (IHC) analyzes of p-Abl1 (Y204) antibody in paraffin-embedded human breast carcinoma tissue./p
/div
/div
div class=list6_li
h3 class=list6_t1Storageamp;Stability/h3
p class=list6_textStore at 4deg;C short term. Aliquot and store at -20deg;C long term. Avoid freeze-thaw cycles./p
/div
div class=list6_li
h3 class=list6_t1Background/h3
p class=list6_textThe Abl oncogene was initially identified as the viral transforming gene of Abelson murine leukemia virus (A-MuLV). The major translational product of c-Abl has been identified as a protein with tyrosine kinase activity and an SH2 domain. The Abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic leukemia (CML), 20-25% of adult acute lymphoblastic leukemia (ALL) and 2-5% of pediatric ALL. In these leukemias the c-Abl proto-oncogene undergoes a (9;22) chromosomal translocation producing the Philadelphia (Ph1) chromosome. The molecular consequence of this translocation is the generation of a chimeric Bcr/c-Abl mRNA encoding activated Abl protein-tyrosine kinase. The Bcr gene has been shown to encode a GTPase-activating protein (GAP) specific for the Ras-related GTP-binding protein, p21rac./p
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