Kits
Osteoprotegerin (OPG) (Serum, EDTA plasma, Heparin pl., Citrate pl.), ELISA
Kits
Description
Osteoprotegerin (OPG) or osteoclast inhibitory factor (OCIF) is a glycoprotein of the
TNF receptor superfamily 11b (gene name TNFRSF11B) http://www.uniprot.org/uniprot/O00300.
OPG is synthesized as a monomer of 380 amino acids and is assembled
as a homodimer within the cell, and then secreted mainly as a disulfide-linked homodimer
into the extracellular compartment. OPG is produced by many different tissues
and cell types including osteoblasts. OPG is a negative regulator of bone resorption
by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis.
This glycoprotein is also involved in the regulation of vascular calcification.
TNF receptor superfamily 11b (gene name TNFRSF11B) http://www.uniprot.org/uniprot/O00300.
OPG is synthesized as a monomer of 380 amino acids and is assembled
as a homodimer within the cell, and then secreted mainly as a disulfide-linked homodimer
into the extracellular compartment. OPG is produced by many different tissues
and cell types including osteoblasts. OPG is a negative regulator of bone resorption
by acting as decoy receptor for RANKL, thus neutralizing its function in osteoclastogenesis.
This glycoprotein is also involved in the regulation of vascular calcification.