Osteoprotegerin (OPG), human recombinant

Alternate Names / Synonyms: Osteoprotegerin, OPG

Gene Symbol: OPG

Accession #: O14789

Gene ID: 8601

Gene Source: Human

Recombinant Host: E. coli

Appearance: Lyophilized protein

Physical Form: Sterile filtered and then lyophilized

Molecular Weight: 20.0 kDa

Purity by SDS-PAGE: ≥98%

Purity by HPLC: ≥98%

Endotoxin Level: <0.1 ng/μg

Biological Activity: Determined by its ability to neutralize the stimulation of U937 cells treated with 10 ng/ml of sRANKL.

Reconstitution: Reconstitute in 5 mM Tris, pH 7.5 to a concentration of 0.1-1.0 mg/ml. The solution can be diluted into other aqueous buffers and stored at 4°C for 1 week or –20°C for future use.

Storage Temp.: -20°C

Shipping: Gel pack

Background Information: Human OPG (Osteoprotegerin), also known as OCIF (Osteoclastogenesis inhibitory factor), is a member of the TNF receptor superfamily. Recombinant human OPG/OCIF specifically acts on bone tissues and increases bone mineral density and bone volume associated with a decrease of active osteoclast number. Recombinant human OPG is a 20 kDa protein, comprising of 174 amino acid residues.

Handling: Centrifuge the vial prior to opening.