Kits
Osteoprotegerin (OPG), ELISA
- 貨號 Cat. No.
- KB1011
- 規格 Size
- 96 Tests
- 品牌 Brand
- IDS
Description
| Article number: | KB1011 |
| Method: | ELISA |
| Tests: | 96 Tests |
| Matrix: | Plasma, Serum, Urine, Cell Culture Supernatant |
| Volume: | 100 µl |
| Incubation time: | 18-24h; 1h; 15min |
| Standards: | 1.1-30 pmol/l |
| Osteoprotegerin (OPG) or Osteoclastogenesis inhibitory factor (OCIF) is a dimeric glycoprotein of the TNF receptor family with a molecular weight of 60 kD resp. 120 kD which shows an inhibitory effect on osteoclasts and osteoclast precursor cells. Osteoprotegerin is a soluble”decoy”-receptor and is produced in different tissues, e.g. bone, skin, liver, stomach, intestine and lung. As a so-called “decoy receptor” OPG inhibits the binding of RANK to RANKL (OPG-L, osteoclast differentation factor, ODF) and thus inhibits the recruitment, proliferation and activation of osteoclasts. OPG shows an inhibitory effect on osteoclasts. Osteoclast formation activity may be determined principally by the relative concentration of OPG-L/osteoclast differentiation factor (ODF) to OPG/OCIF in the bone marrow microenviroment. Alterations of this ratio may be the major cause of bone loss in many imbalances in bone metabolism such as osteoporosis, osteopetrosis, metastatic osteolytic lesions and rheumatic bone degradation. |