Osteocalcin (Mouse) IRMA

pOsteocalcin (Mouse) IRMA/p
pimg alt=For Research Use Only align=absMiddle src=http://www.alpco.com/img/ruo.gif / For Research Use Only/p
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div class=prod_specFormat:/div
div class=prod_spec_infoRadioimmunoassay/div
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div class=prod_specSample Type:/div
div class=prod_spec_infoserum, plasma, cell culture/div
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div class=prod_specbSample Size:/b/div
div class=prod_spec_info10 micro;l/div
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div class=prod_specbSize:/b/div
div class=prod_spec_info100 tests/div
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div class=prod_specbRange:/b/div
div class=prod_spec_info2.5 - 250 ng/ml/div
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div class=prod_specbSensitivity:/b/div
div class=prod_spec_info0.25 ng/ml/div
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div class=prod_specbIncubation Time:/b/div
div class=prod_spec_infoOvernight/div
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pbSummary:/b/p
pMouse osteocalcin, a 46 amino acid peptide, is the major noncollagen protein found in mouse bone. It contains three gamma-carboxyglutamic acid (GLA) residues at positions 13, 17, and 20 and is, therefore, also known as bone gla-protein or BGP. The exact biological function of osteocalcin is not known but the three gamma-carboxyglutamic acid residues confer on it a very strong ability to bind to hydroxyapatite and calcium.br /
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Vitamin K is essential for the biosynthesis of osteocalcin which is stimulated by 1,25-dihydroxyvitamin D. Osteocalcin is synthesized by osteoblasts during the process of bone formation and mostly incorporated into bone matrix with some escaping into the blood. Since the half-life in blood is relatively short (about 5 minutes) the osteocalcin level in blood reflects new protein synthesis and therefore its measurement provides a valuable tool for assessing skeletal metabolism. As a product unique to the osteoblast, it also represents the activity of the cell responsible for the formation of bone.br /
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This assay kit (IRMA) is intended for research use only in the determination of mouse osteocalcin levels in serum, plasma, or cell culture media./p