NVP-TAE684
- 貨號 Cat. No.
- 1683-5
- 規格 Size
- 5 mg
Description
Alternate Name/Synonyms: 5-Chloro-N4-(2-(isopropylsulfonyl)phenyl-N2-(2-methoxy-4-(4-methylpiperazin-1-yl)-piperidin-1-yl)phenyl)pyrimidine-2,4-diamine
Appearance: Light yellow solid
Formulation: N/A
CAS Number: 761439-42-3
Molecular Formula: C₃₀H₄₀ClN₇O₃S
Molecular Weight: 614.2
Purity: ≥98% by HPLC
Solubility: DMSO
Storage Temp.: -20°C
Shipping Conditions: gel pack
Description: A potent and selective ALK (anaplastic lymphoma kinase) inhibitor that blocked the growth of ALCL (anaplastic large cell lymphoma)-derived and ALK-dependent cell lines with ICâ‚…â‚€ = 2-10 nM. NVP-TAE684 treatment resulted in a rapid and sustained inhibition of phosphorylation of NPM-ALK (Nucleophosmin-anaplastic lymphoma kinase) and its downstream effectors and subsequent induction of apoptosis and cell cycle arrest.
Handling: Protect from air and light