NP118809

NP-118809 (39-1B4) is a potent N-type calcium channel blockers (IC50= 0.11 uM) which has good selectivity over L-type calcium channels. NP-118809 exhibites increased N-type channel blockade (IC50=0.11 uM) and is 111-fold more selective for N-type channels (L-type calcium channel IC50=12.2 uM). NP118809 further exhibits a number of favorable preclinical characteristics as they relate to overall pharmacokinetics and minimal off-target activity including the hERG potassium channel.