Nitrofural

Nitrofurazone is a topical anti-infective agent with an IC50 of 22.83 ?1.2 uM, and effective against gram-negative and gram-positive bacteria. (Rat LD50 = 590 mg/kg) Nitrofurazone (NF) and its derivative, hydroxymethylnitrofurazone (NFOH), have presented antichagasic activity. In vitro cruzain inhibition tests were performed for both compounds, and the 50% inhibitory concentration (IC50) for NF and NFOH presented values of 22.83 ?1.2 uM and 10.55 ?0.81 uM, respectively. AM1 semi-empirical molecular modeling studies were performed to understand the activity of the compounds, corroborating the observed cruzain inhibitory activity.