Nimodipine

貨號 Cat. No.: S1747
規格 Size: 10mM/1mLã€50mg
品牌 Brand: Selleckchem

Description

Nimodipine

Catalog No.S1747

Nimodipine is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity.Nimodipine decreases intracellular free Ca2+,Beclin-1 and autophagy.

Size

Price

Stock

Quantity

10mM/1mLIn DMSO	USD 163	In stock	0 1 2 3 4 5 6 7 8 9 10
50mg	USD 122	In stock	0 1 2 3 4 5 6 7 8 9 10

Distributor Tel: +886-2-2827-1197jimmy@new.abscience.com.tw

Biological Activity

Nimodipine(Nimotop) is a dihydropyridine derivative and an analogue of the calcium channel blocker nifedipine, with antihypertensive activity. Nimodipine inhibits the transmembrane influx of calcium ions in response to depolarization in smooth muscle cells, thereby inhibiting vascular smooth muscle contraction and inducing vasodilatation. Nimodipine has a greater effect on cerebral arteries than on peripheral smooth muscle cells and myocardial cells, probably because this agent can cross the blood brain barrier due to its lipophilic nature. Furthermore, this agent also inhibits the drug efflux pump P-glycoprotein, which is overexpressed in some multi-drug resistant tumors, and may improve the efficacy of some antineoplastic agents. [1, 2]

Chemical Information

Download Nimodipine SDF

Molecular Weight (MW)	418.44
Formula	C21H26N2O7
CAS No.	66085-59-4

Storage	3 years -20â„ƒPowder
Storage	6 months-80â„ƒin DMSO
Syonnyms	Nimotop

Solubility (25°C) *	In vitro	DMSO	84 mg/mL (200 mM)
		Water	<1 mg/mL (<1 mM)
		Ethanol	84 mg/mL (200 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Selleck tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.