Nebivolol

Nebivolol (Bystolic) is a β1 receptor blocker with an IC50 of 4.5 µM. It has nitric oxide-potentiating vasodilatory effect used in treatment of hypertension. Nebivolol was compared with DETA-NO and S-nitroso-N-acetylpenicillamine (SNAP), two nitric oxide (NO) donor agents, and alpha-difluoromethylornithine (DFMO), a known inhibitor of ornithine decarboxylase (ODC). All four test agents inhibited RASMC proliferation in a concentration-dependent manner, with nebivolol being the most potent (IC (50) = 4.5 microM), whereas atenolol, another relatively selective beta (1)-blocker, was inactive.