NATL/LAB Antibody

Antibody Target :NTAL/LAB

Host: Rabbit

Antibody Type: Polyclonal

Isotype: Rabbit IgG

Antibody Form: Affinity Purified Antibody

Immunogen Sequence: Synthetic peptide surrounding amino acid 187 of rat NTAL

Accession#: Q8CGL2

Gene ID: 317676

Appearance: Colorless liquid

Concentration: 0.5 mg/ml

Formulation: 100 µg (0.5 mg/ml) affinity purified rabbit polyclonal antibody in phosphate buffered saline (PBS), pH 7.2, containing 30% glycerol, 0.5% BSA, 0.01% thimerosal.

Purification: Affinity purified

Species Reactivity: rt

Application: WB

Application & Usage: Western blotting (0.5-4 µg/ml). However, the optimal conditions should be determined individually. The antibody detects a 22 kDa rat NTAL/LAB. Other species have not been determined.

Storage Temp.: -20 °C

Shipping : gel pack

Shelf Life: 12 months

Handling: The antibody solution should be gently mixed before use.

Brief Background Descriptions: Non-T cell Activation Linker (NTAL) is also known as linker for activation of B cells (LAB), is a transmembrane adaptor protein. NTAL is expressed in B cells, mast cells, monocytes and NK cells. When NTAL is tyrosine phosphorylated, it recruits signalling molecules such as Grb2, Gab2 and c-Cbl into receptor-signalling complexes. Mutation in the NTAL gene may cause Williams-Beuren syndrome, a rare genetic disorder.