Mouse VEGF R3 / FLT4 Protein, Mouse IgG2a Fc Tag, low endotoxin

Source : 

Mouse VEGF R3, Mouse IgG2a Fc Tag, low endotoxin (FL4-M5251) is expressed from human 293 cells (HEK293). It contains AA Tyr 25 - Asp 770 (Accession # P35917-1).

 

Molecule : VEGF R3

 

Synonyms : Flt-4,FLT4,LMPH1A,PCLFLT41,VEGFR3,VEGFR-3,FLT-4,FLT-41,FLT41,PCL

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_032055.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 111.5 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 111.5 kDa. The protein migrates as 116-125 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

Vascular endothelial growth factor receptor 3 (VEGF R3), also known as FLT-4, together with the other two members VEGFR1 (FLT-1) and VEGFR2 (KDR/Flk-1) are receptors for vascular endothelial growth factors (VEGF) and belong to the class III subfamily of receptor tyrosine kinases (RTKs). VEGF R3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D. VEGF R3 is widely expressed in the early embryo but becomes restricted to lymphatic endothelia at later stages of development. It is likely that VEGF R3 may be important for lymph angiogenesis.

 

References :

(1)Stuttfeld E., et al., 2009, IUBMB Life, 61 (9): 915-922.
(2)Zygmunt T., et al., 2011, Dev Cell, 21 (2): 301-314.
(3)Herzog, B., et al., 2011, Molecular Biology of the Cell, 22 (15): 2766-2776.