Mouse Transferrin R2 Protein, mouse IgG1 Fc Tag, low endotoxin

Source : 

Mouse TFR2, Mouse Fc Tag (TF2-M5269) is expressed from human 293 cells (HEK293). It contains AA Arg 103 - Phe 798 (Accession # Q9JKX3-1).

 

Molecule : Transferrin R2

 

Synonyms : Transferrin R2,TFR2

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_056614.3

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 101.1 kDa

 

Characteristics :

This protein carries a mouse IgG1 Fc tag at the N-terminus. The protein has a calculated MW of 101.1 kDa. The protein migrates as 116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.

 

References :

(1) Kawabata H., et al., 2001, Blood 98:1949-1954.