Mouse TIM-3 / HAVCR2 Protein, Fc Tag

Source : 

Mouse TIM-3, Fc Tag (TI3-M5252) is expressed from human 293 cells (HEK293). It contains AA Arg 20 - Arg 191 (Accession # AAL65156.1).

 

Molecule : TIM-3

 

Synonyms : HAVCR2,TIM3,TIMD3,FLJ14428,KIM3

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : AAL65156.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 45.8 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 45.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE).

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Hepatitis A virus cellular receptor 2 is also known as HAVCR2, FLJ14428,  KIM3, TIM3, TIMD3, is a member of the TIM family of immune regulating molecules with one Ig-like V-type domain and a Ser/Thr-rich mucin stalk. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. HAVCR2 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. HAVCR2 regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Dysregulation of the HAVCR2-galectin-9 pathway could underlie chronic autoimmune disease states in human, such as multiple sclerosis.

 

References :

(1) Monney, L. et al., 2002, Nature. 415: 536-41.
(2) Sabatos, CA. et al., 2003, Nat. Immunol. 4: 1102-10.
(3) Anderson, AC. et al., 2006, Curr. Opin. Immunol. 18: 665-9.