Mouse Thrombin

Localization: Plasma Mode of action: Serine protease which cleaves fibrinogen to form fibrin; also responsible for activation of protein C, platelet activation and feedback activation of the procofactors, factor V and factor VIII Molecular weight: 36,700 (3-6) Extinction coefficient: E 1 % 1 c m, 280 nm = 18.3 (human) (6) = 19.5 (bovine) (7) Specific Activity: approximately 3800 NIH units/mg Isoelectric point: 7.0-7.6 (human) (3) Structure: two subunits, approximately Mr=6,000 and 31,000 Percent carbohydrate: approximately 5%