Mouse SLAMF7 / CRACC / CD319 Protein, Mouse IgG2a Fc Tag, low endotoxin

Source : 

Mouse SLAMF7, Mouse IgG2a Fc Tag, low endotoxin (SL7-M5252) is expressed from human 293 cells (HEK293). It contains AA Ala 22 - Gly 224 (Accession # Q8BHK6-1).

 

Molecule : SLAMF7

 

Synonyms : SLAMF7,CD319,CS1,CRACC,19A,FOAP-12

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_653122.2

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 49.4 kDa

 

Characteristics :

This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 49.4 kDa. The protein migrates as 55-70 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 0.1 EU per μg by the LAL method.

 

Buffer : 50 mM Tris, 100 mM Glycine, pH7.5

 

Description :

SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), Membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. Isoform 1 of SLAMF7 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway. May play a role in lymphocyte adhesion. Isoform 3 of SLAMF7 does not mediate any NK cell activation.

 

References :

(1) Bouchon A., et al., 2001, J. Immunol. 167:5517-5521.
(2) Murphy J.J., et al., 2002, Biochem. J. 361:431-436.