Mouse SIRP alpha / CD172a Protein, His Tag

Source : 

Mouse SIRP alpha, His Tag (SIA-M52H4) is expressed from human 293 cells (HEK293). It contains AA Lys 32 - Asn 373 (Accession # BAA13520.1).

 

Molecule : SIRP alpha

 

Synonyms : SHPS1,SIRPA,CD172A,BIT,MFR,MYD1,P84,PTPNS1

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : BAA13520.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 39.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.8 kDa. The protein migrates as 60-80 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Tyrosine-protein phosphatase non-receptor type substrate 1 (SHPS1) is also known as CD172 antigen-like family member A (CD172a), Macrophage fusion receptor, MyD-1 antigen, Signal-regulatory protein alpha (SIRPA or SIRP alpha) or p84, is a member of the SIRP family, and also belongs to the immunoglobulin superfamily. SIRP alpha is Ubiquitous and highly expressed in brain. SIRPA / CD172a is immunoglobulin-like cell surface receptor for CD47 and acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA / SHPS-1 supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment and may play a key role in intracellular signaling during synaptogenesis and in synaptic function By similarity. SIRPA / MyD1 involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin and mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.

 

References :

(1) Timms J.F., et al., 1999, Curr. Biol. 9:927-930.
(2) Stofega M.R., et al., 2000, J. Biol. Chem. 275:28222-28229.
(3) Latour S., et al., 2001, J. Immunol. 167:2547-2554.