Mouse Siglec-2 / CD22 Protein, His Tag

Source : 

Mouse Siglec-2, His Tag (SI2-M52Ha) is expressed from human 293 cells (HEK293). It contains AA Ser 22 - Arg 702 (Accession # P35329-1).

 

Molecule : Siglec-2

 

Synonyms : CD22,SIGLEC2,BL-CAM,SIGLEC-2,Siglec2,SIGLEC2FLJ22814

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : P35329.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 78.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 78.3 kDa. The protein migrates as 100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin) family. CD22 mediates B-cell B-cell interactions, and may be involved in the localization of B-cells in lymphoid tissues. Siglec-2 / CD22 binds sialylated glycoproteins, one of which is CD45. Siglec2 / CD22 plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.

 

References :

(1) Hatta Y., et al., 1999, Immunogenetics 49:280-286.
(2) Doody G.M., et al., 1995, Science 269:242-244.
(3) Tuscano J.M., et al., 1996, Eur. J. Immunol. 26:1246-1252.