Mouse polyclonal antibody to human Siah-1
Antibodies
- 貨號 Cat. No.
- M-867-50
- 規格 Size
- 50 µL
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Polyclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
E3 ubiquitin-protein ligase SIAH1; Seven in absentia homolog 1; Siah-1a; SIAH1; HUMSIAH
Antibody_Isotype
(Antibody only) :
Application_Details :
This antibody is recommended for ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) :
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=353
Description (Long Description) :
Siah-1 is a member of the seven in absentia homolog (SIAH) family. It is a E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, including many proteins involved in transcription regulation, a cell surface receptor (DCC), cytoplasmic signal transduction molecules, an antiapoptotic protein (BAG1), a microtubule motor protein (KIF22), a protein involved in synaptic vesicle function in neurons (SYP) and a structural protein. Consequently Siah-1 is involved in many cellular processes such as apoptosis, tumor suppression, cell cycle, axon guidance, transcription regulation, spermatogenesis, and TNF-alpha signaling. It is predominantly a cytoplasmic protein but is also partially a nuclear protein. It is widely expressed at low levels and is down-regulated in advanced hepatocellular carcinomas.
Expiry_Date :
12 months after purchase
Format (Form) :
Liquid with 50% glycerol
Immunogen (Antigen) :Partial recombinant human Siah-1 (amino acids 1-110) with a GST tag.
Kit_Components :
MSDS (File name) :
