Mouse polyclonal antibody to human Notch 2: whole serum
Antibodies
- 貨號 Cat. No.
- Mo-933-50
- 規格 Size
- 50 µL
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Polyclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Neurogenic locus notch homolog protein 2; hN2; NOTCH2
Antibody_Isotype
(Antibody only) : Mixed
Application_Details :
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) :
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=409
Description (Long Description) :
Notch 2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBP-J kappa and activates genes of the enhancer of split locus. Notch 2 is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. It is expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Defects in Nothch 2 are the cause of Alagille syndrome type 2 which is a multisystem disorder defined by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal and opthalmologic manifestations.
Expiry_Date :
12 months after purchase
Format (Form) :
Liquid. 50% glycerol
Immunogen (Antigen) :Partial recombinant human Notch 2 (26-136) with a GST tag.
Kit_Components :
MSDS (File name) :
