Mouse PLGF / PGF Protein, His Tag

Source : 

Mouse PLGF, His Tag (PGF-M52H0) is expressed from human 293 cells (HEK293). It contains AA Val 19 - Pro 158 (Accession # P49764-1).

 

Molecule : PLGF

 

Synonyms : PGF,PLGF,PlGF2,PlGF,PGFL,SHGC-10760

 

Format : Powder

 

Category : Bio-Markers & CD Antigens

 

Accession : NP_032853.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 17.8 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 17.8 kDa. The protein migrates as 27-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : 100 mM HAC, pH2.5

 

Description :

Placental growth factor (PGF) is also known as vascular endothelial growth factor-related protein, PLGF and PlGF2, is a member of the VEGF (vascular endothelial growth factor) sub-family - a key molecule in angiogenesis and vasculogenesis, in particular during embryogenesis. The main source of PGF during pregnancy is the placental trophoblast. PGF is also expressed in many other tissues, including the villous trophoblast. PGF is actived in angiogenesis and endothelial cell growth, stimulating their proliferation and migration. PlGF2 binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner. Also promotes cell tumor growth.

 

References :

(1) Maglione D., et al., 1993, Oncogene 8 (4): 925–31.
(2) Khalil A., et al., 2008, PLoS ONE 3 (7): e2766.
(3) Khurana R., et al., 2005, Circulation 111 (21): 2828–2836.
(4) Rolny C., et al., 2011, Cancer Cell 19:31-44.