Mouse PD-L2 / B7-DC Protein, Fc Tag

Source : 

Mouse PD-L2, Fc Tag (PD2-M5254) is expressed from human 293 cells (HEK293). It contains AA Leu 20 - Arg 219 (Accession # NP_067371).

 

Molecule : PD-L2

 

Synonyms : PDL2,PD-L2,Butyrophilin B7-DC,CD273,PDCD1 ligand 2,PDCD1L2,PDCD1LG2

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_067371

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 49.2 kDa

 

Characteristics :

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 49.2 kDa. As a result of glycosylation, the protein migrates as 60-70 kDa under reducing (R) condition, and 120-140 kDa under non-reducing (NR) condition (SDS-P

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : Tris with Glycine, Arginine and NaCl, pH7.5

 

Description :

Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is also known as Butyrophilin B7-DC, CD antigen CD273, which belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4. PD-L2 Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. PD-L2 interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

 

References :

(1) Tseng S.-Y., et al., 2001, J. Exp. Med. 193:839-846.
(2) Latchman Y., et al., 2001, Nat. Immunol. 2:261-268.
(3) He X.-H., et al., 2004, Acta Biochim. Biophys. Sin. 36:284-289.