Mouse OX40 Ligand / TNFSF4 Protein, His Tag

Source : 

Mouse OX40 Ligand, His Tag (TN4-M5241) is expressed from human 293 cells (HEK293). It contains AA Gln 49 - Leu 198 (Accession # P43488-1).

 

Molecule : OX40 Ligand

 

Synonyms : OX40L,TNFSF4,CD252,Glycoprotein Gp34,TXGP1,CD134 ligand,CD134L

 

Format : Powder

 

Category : Immune Checkpoint Proteins

 

Accession : NP_033478.1

 

Storage : -20℃

 

Shipping condition : Powder,RT

 

Molecular Weight : 18.3 kDa

 

Characteristics :

This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.3 kDa. The protein migrates as 20 kDa and 22-25 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

 

Endotoxin Level : Less than 1.0 EU per μg by the LAL method.

 

Buffer : PBS, pH7.4

 

Description :

Tumor necrosis factor ligand superfamily member 4 (TNFSF4) is also known as glycoprotein Gp34, OX40 ligand (OX40L), TAX transcriptionally-activated glycoprotein 1 and CD252, which belongs to the tumor necrosis factor family. TNFSF4 is the ligand for CD134 and is expressed on such cells as DC2s (a subtype of dendritic cells) enabling amplification of Th2 cell differentiation. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. Furthermore, similar to other TNF superfamily members, membrane-bound OX40 Ligand (TNFSF4) exists as a homotrimer. Human TNFSF4 shares 46% amino acid sequence identity with its mouse counterpart.

 

References :

(1) Compaan D.M., et al., 2006, Structure 14:1321-1330.
(2) Maizels RM., et al., 2003, Nat. Rev. Immunol. 3 (9): 733–44.