Mouse monoclonal to Fox1 [Ataxin-2 binding protein1, A2BP1]

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

ataxin-2 binding protein 1 (A2BP1); RNA binding protein fox-1 homolog 1

 

Antibody_Isotype
(Antibody only) : IgG1

 

Application_Details :

Immunocytochemistry (IHC) and Western Blotting (WB). A dilution of 1:1,000-1:2,000 is recommended for WB. A dilution of 1:500-1:1000 is recommended for ICC. The optimal dilution should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : 1G10

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1268

 

Description (Long Description) : 

Fox1 is one of a family of 3 mammalian Fox1 homologues. Fox1 was discovered in C. elegans as a gene involved in sex determination, and the name Fox is an acronym of "Feminizing locus on X" (1). The C. elegans Fox1 protein and its 3 mammalian homologues are all about 46kDa proteins and each includes a central highly conserved RRM type RNA recognition motif, which corresponds to a small ~70 amino acid structure consisting of 4 beta strands and two alpha-helices. This region is identical in all three mammalian Fox1 family proteins. An alternate name for Fox 1 is ataxin-2 binding protein 1 (A2BP1), since it was discovered in a yeast two hybrid screen using ataxin-2 as bait (2). As with the other Fox proteins, it is assumed that Fox1/A2BP1 has a role in the RNA splicing in the nervous system (3). Fox3, a protein also known as NeuN, is a widely used marker of neuronal nuclei and proximal cytoplasm (4, 5). Like Fox3, Fox1 is expressed in neuronal nuclei, but with a different pattern of expression than Fox3. For example, in the cerebellum Fox3 does not stain Purkinje neurons and Golgi neurons, but these two neuron types are stained by Fox1 antibody (6).

 

Expiry_Date : 

12 months after purchase

 

Format (Form) : 

Lyophilized from PBS. Contains 5% trehalose.

 

Immunogen (Antigen) :N-terminal 100 amino acids of human Fox1 as expressed in and purified from E. coli.

 

Kit_Components :

 

MSDS (File name) :