Mouse monoclonal antibody to the human Tyrosine kinase receptor type B [4D3-F10]: IgG
Antibodies
- 貨號 Cat. No.
- M-853-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Tropomyosin-related kinase receptor; BDNF/NT-3 growth factors receptor; Neurotrophic tyrosine kinase receptor type 2; TrkB tyrosine kinase; GP145-TrkB; Trk-B; TrkB; NTRK2; TRKB
Antibody_Isotype
(Antibody only) : IgG2a, kappa
Application_Details :
This antibody is recommended for WB, sandwich ELISA and Flow Cytometry. Use 2 ug/10^6 cells for Flow Cytometry. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 4D3-F10
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=339
Description (Long Description) :
Tyrosine kinase receptor type B (TrkB) is a member of the neurotrophic tyrosine receptor kinase family. It is a membrane-bound receptor and upon neurotrophin binding, it phosphorylates itself as well as MAPK pathways members. TrkB is the receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5, but not nerve growth factor (NGF). It is involved in the development and/or maintenance of the nervous system. It exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. It is a tran-membrane protein. There are 3 named isoforms produced by alternative splicing. Additional isoforms seem to exist. The different forms are differentially expressed in various cell types including neurons and microglia.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS pH 7.2
Immunogen (Antigen) :Recombinant protein of human Tyrosine kinase receptor type B (isoform TrkB-T1) with a GST tag.
Kit_Components :
MSDS (File name) :
