Mouse monoclonal antibody to rh BDNF [3C11]: IgG

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Brain-derived neurotrophic factor; Abrineurin; proBDNF

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

ELISA (50-100 ng/mL), WB (0.2 to 2 µg/mL), IF (2 to 20 µg/mL). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : 3C11

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1564

 

Description (Long Description) : 

BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

 

Expiry_Date : 

12 months after purchase if unopened.

 

Format (Form) : 

Lyophilized from a solution containing PBS pH 7.4, 3% trehalose, with 0.1% sodium azide.

 

Immunogen (Antigen) :Recombinant human mature BDNF expressed in E.coli

 

Kit_Components :

 

MSDS (File name) :