Mouse monoclonal antibody to P Glycoprotein [PG-13]: IgG

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Multidrug resistance protein 1; ATP-binding cassette sub-family B member 1; P-glycoprotein 1; CD243; ABCB1; MDR1; PGY1;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Immunohistochemistry (IHC) and Western Blotting (WB). A concentration of 0.5-1.0 µg/mL is recommended for WB. Human P Glycoprotein has a predicted length of 1280 residues and MW of 141 kDa. A concentration of 1.0-2.0 µg/mL is recommended for IHC to detect the protein in formalin fixed and paraffin embedded tissues. Heat mediated antigen retrieval is required. A concentration of 1.0-2.0 µg/mL is recommended for IHC to detect the protein in formalin/acetone fixed frozen tissues. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : PG-13

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=686

 

Description (Long Description) : 

P Glycoprotein belongs to the MDR/TAP subfamily of ATP-binding cassette (ABC) transporters. P Glycoprotein is an ATP-dependent drug efflux pump expressed in liver, kidney, small intestine and brain. It is responsible for decreased drug accumulation in multidrug-resistant cells. Genetic variation in P Glycoprotein is thought to play a role in patients who do not respond to drug treatment. P Glycoprotein also functions as a transporter in the blood-brain barrier.

 

Expiry_Date : 

12 months after purchase

 

Format (Form) : 

Lyophilized from 1.2% sodium acetate, 2mg BSA, 0.01mg NaN3

 

Immunogen (Antigen) :Human and hamster drug-resistant whole cells and crude plasma membranes

 

Kit_Components :

 

MSDS (File name) :