Mouse monoclonal antibody to human TPP-1 [3B1]: IgG
Antibodies
- 貨號 Cat. No.
- M-802-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 IHC, Frozen 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Tripeptidyl-peptidase 1; TPP-l; Tripeptidyl aminopeptidase; Lysosomal pepstatin-insensitive protease; LPIC; Cell growth-inhibiting gene 1 protein; TPP1; CLN2
Antibody_Isotype
(Antibody only) :
Application_Details :
This antibody is recommended for direct and sandwich ELISA, IHC and WB. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 3B1
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=318
Description (Long Description) :
TPP1 is a lysosomal serine protease with tripeptidyl-peptidase I activity. It may act as a non-specific lysosomal peptidase which releases an N-terminal tripeptide from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. TPP1 is detected in lysosomes and melanosomes in all tissues but it is highest in the heart and placenta. TPP1 is activated by autocatalytic proteolytic processing upon acidification within lysosomes. Defects in TPP1 cause classical late-infantile neuronal ceroid lipofuscinosis (LINCL) which is also known as ceroid lipofuscinosis 2 (CLN2). It is a fatal childhood neurodegenerative disease characterised by progressive visual and mental deterioration, motor disturbance, epilepsy and behavioural changes.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS, pH 7.6
Immunogen (Antigen) :Partial recombinant protein of human TPP1 (amino acids 195 to 305) with a GST tag.
Kit_Components :
MSDS (File name) :
