Mouse monoclonal antibody to human NTN (Neurturin) [1B11]: IgG

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

 

Antibody_Isotype
(Antibody only) : IgG1

 

Application_Details :

Western blot (WB) at a suggested dilution of 1:5,000-1:10,000. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : 1B11

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1259

 

Description (Long Description) : 

Neurturin (NTN) is a member of the GDNF family of neurotrophic factors. This protein is a potent survival factor for several populations of central and peripheral neurons in mature and developing rodents. FUNCTION: Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells. SUBUNIT: Homodimer; disulfide-linked. SUBCELLULAR LOCATION: Secreted protein. DISEASE: Defects in NRTN are a cause of Hirschsprung disease (HSCR). In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction. SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.

 

Expiry_Date : 

12 months after date of receipt

 

Format (Form) : 

PBS pH 7.4, with 0.1% sodium azide

 

Immunogen (Antigen) :Recombinant human NRTN protein produced using CHO-based suspension cell line. Protein was purified from the cell culture supernatant.

 

Kit_Components :

 

MSDS (File name) :