Mouse monoclonal antibody to human NGFR/p75NTR [8J2] - ATTO 488
Antibodies
- 貨號 Cat. No.
- M-1821-50-AT
- 規格 Size
- 50 µg
- 品牌 Brand
- Biosensis
- Application 應用
- fc 、 IC
- Reactivity
- Human 、 Mouse 、 Rat
- Host
- Mouse
- Clonality
- Monoclonal
- Conjugate
- ATTO 488. Typical Fluorophore/Protein (F/P) - ratio is 3-10.
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Low-affinity nerve growth factor receptor; NGF receptor; Gp80-LNGFR; p75 ICD; Low affinity neurotrophin receptor p75NTR
Antibody_Isotype
(Antibody only) : IgG2a
Application_Details :
Immunocytochemistry: 1-5 µg/mL. Light fixation only, or unfixed works best. Epitope is sensitive to fixation.
Flow Cytometry: 5-20 ug/mL.
Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 8J2
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=1652
Description (Long Description) :
p75NTR (CD271) was originally discovered as a low affinity nerve growth factor receptor (NGFR). Later it was found that it was the receptor for all neurotrophins, including NGF, BDNF, NT3 and NT4/5. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. Recent research proposes the extracellular domain of p75NTR as a biomarker for monitoring the progression of motor neuron disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3.
Expiry_Date :
4 months after purchase if unopened.
Format (Form) :
Liquid antibody (1 mg/mL) in PBS, pH 7.2-7.6, without preservative.
Immunogen (Antigen) :Recombinant extracellular domain (amino acids 29-250) of human NGFR/p75NTR protein with N-terminal His-tag.
Kit_Components :
MSDS (File name) :
