Mouse monoclonal antibody to human NeuroD1 [3H8]: IgG
Antibodies
- 貨號 Cat. No.
- M-850-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 IHC, Frozen 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Neurogenic differentiation factor 1; NeuroD; NEUROD1; NEUROD
Antibody_Isotype
(Antibody only) : IgG2a
Application_Details :
This antibody is recommended for WB, IHC, sandwich ELISA, immunofluorescence, Flow Cytometry. The recommended dilution for this antibody is 3 µg/mL for IHC and 10 µg/mL for immunofluorescence. Use ~2 ug per 10^6 cells for Flow Cytometry. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 3H8
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=336
Description (Long Description) :
NeuroD1 is a differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. It is a transcriptional activator and binds to the insulin gene E-box. Efficient DNA binding requires dimerisation with another basic helix-loop-helix protein. In islet cells, NeuroD1 is phosphoryated on Ser-274 upon glucose stimulation and in activated neurons it is phosphorylated on Ser-335, which promotes dendritic growth. Defects in NeuroD1 cause maturity onset diabetes of the young type 6 (MODY6). It is characterised by the onset of diabetes during young adulthood and a primary defect in insulin secretion.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS pH 7.2
Immunogen (Antigen) :Partial recombinant human NeuroD1 (201-300) with a GST tag.
Kit_Components :
MSDS (File name) :
