Mouse monoclonal antibody to human GremLin-1 [4C2]: IgG
Antibodies
- 貨號 Cat. No.
- M-877-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Cysteine knot superfamily 1 BMP antagonist 1; Increased in high glucose protein 2; IHG-2; Down-regulated in Mos-transformed cells protein; DAN domain family member 2; Cell proliferation-inducing gene 2 protein GREM1; CKTSF1B1; DAND2; DRM
Antibody_Isotype
(Antibody only) : IgG2a Kappa
Application_Details :
This antibody is recommended for WB and sandwich ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 4C2
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=378
Description (Long Description) :
GremLin-1 is a secreted cytokine that may play a role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. It down-regulates the BMP4 signaling in a dose-dependent manner. It also acts as inhibitor of monocyte chemotaxis. It is highly expressed in small intestine, fetal brain and colon. Weakly expressed in brain, ovary, prostate, pancreas and skeletal muscle. In brain found in the region localized around the internal capsule in the large subcortical nuclei, including caudate, putamen, substantia nigra, thalamus and subthalamus. Predominantly expressed in normal cells including neurons, astrocytes and fibroblasts. GremLin-1 is induced through TGF-beta 1-mediated pathways in Mesangial cell and it is down-regulated in tumor cell lines.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS pH 7.4
Immunogen (Antigen) :Partial recombinant human GremLin-1 (75-184) with a GST tag.
Kit_Components :
MSDS (File name) :
