Mouse monoclonal antibody to human ATG5 [4B2]: IgG
Antibodies
- 貨號 Cat. No.
- M-882-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Autophagy protein 5; APG5-like; Apoptosis -specific protein; ATG5; APG5L; ASP; APG6
Antibody_Isotype
(Antibody only) : IgG2a, kappa
Application_Details :
This antibody is recommended for WB, sandwich ELISA, Flow Cytometry (~2 ug per 10^6 cells). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 4B2
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=367
Description (Long Description) :
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG5 conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. ATG5 may also play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. It localise to the cytoplasm and it co-localise with nonmuscle actin. ATG5 is ubiquitously expressed. Its expression is dramatically increased in apoptotic cells. Conjugation to ATG12 is essential for autophage but it is not required for association with isolation membrane.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS pH 7.2
Immunogen (Antigen) :Partial recombinant human ATG5 (176-275) with a GST tag.
Kit_Components :
MSDS (File name) :
