Mouse monoclonal antibody to human Acute-phase response factor [1D11]: IgG
Antibodies
- 貨號 Cat. No.
- M-870-100
- 規格 Size
- 100 µg
- 品牌 Brand
- Biosensis
- Application 應用
- ELISA 、 WB
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
Description
ZZZZ_Status (Active, Disc) : Active
AA_Supplier Name : Biosensis
Alternative_Name (Other Names) :
Signal transducer and activator of transcription 3; STAT3; APRF
Antibody_Isotype
(Antibody only) :
Application_Details :
This antibody is recommended for WB and ELISA. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.
Background_Info :
Clone_Name
(AB only, monoclonals) : 1D11
Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=356
Description (Long Description) :
Acute-phase response factor is a transcription factor that binds to the IL-6-responsive elements identified in the promoters of various acute-phase protein genes. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. Once phosphorylated, the protein is translocated into the nucleus. It forms a homodimer or a heterodimer with a related family member (STAT1). It is expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Defects in Acute-phase response factor are the cause of hyperimmunoglobulin E recurrent infection syndrome autosomal dominant (AD-HIES). This disorder is characterised by immunodeficiency, chronic eczema, recurrent Staphylococcal infections, increased serum IgE, eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
Expiry_Date :
12 months after purchase
Format (Form) :
Lyophilized from PBS pH 7.2
Immunogen (Antigen) :Recombinant human Acute-phase response factor with GST tag.
Kit_Components :
MSDS (File name) :
