Mouse monoclonal antibody to Cyclin-dependent kinase inhibitor 2A [IMD-16]: IgG

ZZZZ_Status (Active, Disc) : Active

 

AA_Supplier Name : Biosensis

 

Alternative_Name (Other Names) :

Cyclin-dependent kinase 4 inhibitor A; CDK4I; p16-INK4a; p16INK4A; p16-INK4; Multiple tumor suppressor 1; MTS-1; CDKN2A; CDKN2; MTS1;

 

Antibody_Isotype
(Antibody only) :

 

Application_Details :

Immunohistochemistry (IHC) and Western Blotting (WB). A concentration of 0.5-1.0 µg/mL is recommended for WB. Human CDK2NA (isoform 1, p16INK4A) has a predicted length of 156 residues and MW of 17 kDa. A concentration of 1.0-2.0 µg/mL is recommended to detect the protein in formalin fixed and paraffin embedded tissues. Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

 

Background_Info :

 

Clone_Name
(AB only, monoclonals) : IMD-16

 

Datasheet_Link : http://www.biosensis.com/pdf_datasheet.php?products_id=683

 

Description (Long Description) : 

The Cyclin-dependent kinase inhibitor 2A (CDK2NA) gene encodes several transcripts which differ from each other in their first exons.  In spite of the structural and functional differences of these transcripts, they are all involved in cell cycle G1 control. Isoform 1, also known as p16INK4A, acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6 kinases. This antibody reacts specifically with this isoform (p16INK4A).

 

Expiry_Date : 

12 months after purchase.

 

Format (Form) : 

Lyophilized from 1.2% sodium acetate, 2mg BSA, 0.01mg NaN3

 

Immunogen (Antigen) :Recombinant human Cyclin-dependent kinase inhibitor 2A

 

Kit_Components :

 

MSDS (File name) :